HƯỚNG NGHIÊN CỨU

1. Lĩnh vực Di truyền Y học:

  • Di truyền và sản phụ khoa.
  • Di truyền và chậm phát triển tâm thần/dị tật bẩm sinh.
  • Di truyền và ung thư.
  • Yếu tố di truyền người (vật chủ) và vi sinh vật trong các cơ chế và điều trị bệnh.
  • Ứng dụng các kỹ thuật sinh học phân tử trong phân tích gene, genome.

2. Lĩnh vực Vi sinh:

  • Dịch tễ học phân tử nhiễm trùng các virus cúm và các virus gây nhiễm trùng hô hấp, các Enterovirus gây bệnh tay chân miệng, virus dengue gây sốt xuất huyết, HPV gây ung thư cổ tử cung và u nhú tình dục.
  • Dịch tễ học phân tử và chẩn đoán các vi khuẩn gồm vi khuẩn lao (Mycobacteria tuberculosis và lao kháng thuốc, liên cầu lợn (Streptococus suis), chẩn đoán và nghiên cứu đột biến kháng thuốc của các vi khuẩn Helicobacter pylori… chẩn đoán phân tử các Mycoplasma gây nhiễm trùng đường sinh dục.
  • Phát triển/Áp dụng các kỹ thuật phân tử để xác định các vi khuẩn và virus nhiễm trùng mới và tái xuất hiện.
  • Ứng dụng sinh học phân tử trong định danh loài vi khuẩn bằng kỹ thuật giải trình tự gen và genome vi sinh vật
  • Các vi khuẩn gây nhiễm khuẩn bệnh viện: dịch tễ học lâm sàng, dịch tễ học phân tử, tính kháng thuốc của các vi khuẩn gây nhiễm khuẩn bệnh viện như MRSA, E. coli, Ps. aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, E. coli, MRSA.
  • Phát triễn các cơ sở dữ liệu khoa học, công cụ khai phá dữ liệu trên các nền tảng điện toán đám mây phục vụ nghiên cứu khoa học, khám và chữa bệnh.

 

ĐỀ TÀI KHOA HỌC

Cấp Trường | 5/2018 - 5/2019 | Đã nghiệm thu
Khảo sát tính kháng thuốc kháng sinh và một số đặc trưng về gen của các chủng Klebsiella pneumoniae gây nhiễm khuẩn tại Bệnh viện trường Đại học Y Dược Huế


CÔNG BỐ KHOA HỌC

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5. Nguyen T, Le Q, Hoang DT, et al. Massively parallel sequencing uncovered disease‐associated variant spectra of glucose‐6‐phosphate dehydrogenase deficiency, phenylketonuria and galactosemia in Vietnamese pregnant women. Molecular Genetics & Genomic Medicine. 2022;10(7). doi: 10.1002/mgg3.1959

6. Le PTQ, Le TNU, Nguyen TTB, Nguyen MT, Ha TMT. An Extremely Rare SRD5A2 Gene c485A>C Mutation in a Compound Heterozygous Newborn with Disorders of Sex Development First Identified in Vietnam. Case Reports in Endocrinology. 2022;2022:1-5. doi: 10.1155/2022/6025916

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8. Le TNU, Ha TMT. MBD5‐ related intellectual disability in a Vietnamese child. American Journal of Medical Genetics Part A. 2021;185(4):1321-1323. doi: 10.1002/ajmg.a.62077

9. Ha TMT, Nguyen TTN, Nguyen TMN, Nguyen HN. De novo c2455C>T mutation of NPR2 gene in a fetus with shortened long bones and a ventricular septal defect conceived by a mother with a fragile site at 16q221 and a father with a rare heterochromatic variant of chromosome 4 from Vietnam. Molecular Genetics & Genomic Medicine. 2021;9(4). doi: 10.1002/mgg3.1637

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13. Tran VH, Ha TMT, Le PTQ, Phan TN, Tran TNH. Characterisation of point mutations in domain V of the 23S rRNA gene of clinical Helicobacter pylori strains and clarithromycin-resistant phenotype in central Vietnam. Journal of Global Antimicrobial Resistance. 2019;16:87-91. doi: 10.1016/j.jgar.2018.09.012

14. Tran VH, Ha TMT, Le PTQ, Nguyen VN, Phan TN, Paglietti B. Helicobacter pylori 23S rRNA gene mutations associated with clarithromycin resistance in chronic gastritis in Vietnam. The Journal of Infection in Developing Countries. 2018;12(07):526-532. doi: 10.3855/jidc.10000

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6. Giordo R, Cossu A, Pasciu V, Hoa PT, Posadino AM, Pintus G. Different Redox Response Elicited by Naturally Occurring Antioxidants in Human Endothelial Cells. The Open Biochemistry Journal. 2013;7:44-53. doi: 10.2174/1874091X01307010044

1. Thi Minh Chau Ngo, Antonella Santona, Maura Fiamma, Phuong Anh Ton Nu, Thi Bich Thao Do, Piero Cappuccinelli, Bianca Paglietti. 2023. Azole non-susceptible C. tropicalis and polyclonal spread of C. albicans in Central Vietnam hospitals. The Journal of Infection in Developing Countries: 17 (04): 550-558. doi: 10.3855/jidc.17574

2. Le Chi Cao, Vanessa Martin, Le Thi Kieu Linh, Tran Thi Giang, Ngo Thi Minh Chau, Ton Nu Phuong Anh, Vu Xuan Nghia, Nguyen Trong The, Truong Nhat My, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, C.-Thomas Bock, Thirumalaisamy P. Velavan. 2023. High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors. Viruses: 15 (10): 2075. doi: 10.3390/v15102075

3. Margarita V, Cao LC, Bailey NP, et al. Effect of the Symbiosis with Mycoplasma hominis and Candidatus Mycoplasma Girerdii on Trichomonas vaginalis Metronidazole Susceptibility. Antibiotics. 2022;11(6):812. doi: 10.3390/antibiotics11060812

4. Tran Thi G, Azzena I, Scarpa F, et al. Molecular Identification and Appraisal of the Genetic Variation of Taenia saginata in Central Regions of Vietnam. Life. 2022;12(1):70. doi: 10.3390/life12010070

5. Ngo TMC, Ton Nu PA, Le CC, et al. Nannizzia incurvata in Hue city - Viet Nam: Molecular identification and antifungal susceptibility testing. Journal of Medical Mycology. 2022;32(3):101291. doi: 10.1016/j.mycmed.2022.101291

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7. Ton Nu PA, Ngo TMC, Nguyen Phuoc V, Dang Nhu T, Do Ngoc A, Cao LC. Biliary fascioliasis – A rare differential diagnosis of biliary obstruction. The Journal of Infection in Developing Countries. 2022;16(10):1664-1667. doi: 10.3855/jidc.16037

8. Ngo TMC, Ton Nu PA, Cao LC, Thuy Ha TN, Thao Do TB, Thi GT. A case of onychomycosis caused by a terbinafine-susceptible Fusarium solani in Vietnam. Iranian Journal of Microbiology. 2022. doi: 10.18502/ijm.v14i6.11269

9. Xuan Hai T, Thai Ngoc Minh N, Ngoc Anh D, Ngoc Dung T, Thi Minh Chau N, Tran-Anh L. A rare Fusarium equiseti infection in a 53-year-old male with burn injury: A case report. Current Medical Mycology. 2021. doi: 10.18502/cmm.7.1.6245

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1. Thi Thanh Ngoc Le, Thi Kieu Nhi Nguyen, Van Minh Nguyen, Thi Cam Minh Dao, Hoai Bao Chau Nguyen, Cong Thuan Dang, Thi Bao Chi Le, Thi Khanh Linh Nguyen, Phuong Thao Tien Nguyen, Le Hoang Nam Dang, Van Minh Doan, Hoang Nhan Ho. 2023. Development and Characterization of a Hydrogel Containing Curcumin-Loaded Nanoemulsion for Enhanced In Vitro Antibacteria and In Vivo Wound Healing. Molecules: 28 (17): 6433. doi: 10.3390/molecules28176433

2. Tam Chau HT, Ha Nguyen PN, Nguyen HB. Genotyping of Mycobacterium leprae strains in south central coast and central highlands of Vietnam. Iranian Journal of Microbiology. 2023. doi: 10.18502/ijm.v15i2.12470

3. Tram NVQ, Thuy PTT, Khoa NTD, et al. Characteristics of Antibiotic-resistant E coli Isolated from Perfume River in Hue City, Vietnam. Journal of Pure and Applied Microbiology. 2023;17(2):1076-1085. doi: 10.22207/JPAM.17.2.37

4. Nguyen, H. B., Ho, T. T. M., Lea, R.. Rapid bacterial identification from clinical specimens by using the MinION™ sequencing device: A pilot study. Malaysian Journal of Microbiology. 2023. doi: 10.21161/mjm.220086

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6. Tam Le M, Nguyen Nguyen D, Bach Nguyen H, Quynh Tram Ngo V, Quoc Huy Nguyen V. Ureaplasma urealyticum and Mycoplasma genitalium detection and sperm quality: A cross-sectional study in Vietnam. International Journal of Reproductive BioMedicine (IJRM). 2022:185-194. doi: 10.18502/ijrm.v20i3.10710

7. Nguyen H, Linh Nguyen TK, Ung TT, Nhi Mai TT, Hoa Tran TN, Tram Ngo VQ, An Le V. Case of misdiagnosed melioidosis from Hue city, Vietnam. Iran J Microbiol. 2022;14(3):430-433.

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13. Le MT, Nguyen VQH, Nguyen LNT, Ngo VQT, Nguyen HB, Cao NT. Is Chlamydia trachomatis PCR Detection from Cervical Canal Swabs Associated with Tubal Obstruction?. Fertility & Reproduction. 2020;02(01):3-8. doi: 10.1142/S2661318220500012

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1. Giuliani C, Biggs D, Nguyen TT, et al. First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population. Environmental Pollution. 2018;242:976-985. doi: 10.1016/j.envpol.2018.07.015

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4. Fiamma M, Longoni SS, Ngo TMC, et al. Fasciolopsis buski infection in a Vietnamese pregnant woman with systemic lupus erythematosus. The Journal of Infection in Developing Countries. 2015;9(06):670-673. doi: 10.3855/jidc.7017

1. Nguyen TTU, Kim H, Chae YJ, Jung JH, Kim W. Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease. Medicine. 2022;101(7):e28804. doi: 10.1097/MD.0000000000028804

2. Nguyen Thanh T, Nguyen Tran BS, Hoang Thi AP, et al. HER2Ile655Val Single Nucleotide Polymorphism Associated with Early-Onset Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis. Asian Pacific Journal of Cancer Prevention. 2021;22(1):11-18. doi: 10.31557/apjcp.2021.22.1.11

3. Nguyen TTU, Yeom J, Kim W. Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences. 2021;22(21):11923. doi: 10.3390/ijms222111923

4. Nguyen TTU, Kim HW, Kim W. Effects of Probiotics, Prebiotics, and Synbiotics on Uremic Toxins, Inflammation, and Oxidative Stress in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine. 2021;10(19):4456. doi: 10.3390/jcm10194456

5. Dang Cong T, Nguyen Thanh T, Nguyen Phan QA, Hoang Thi AP, Nguyen Tran BS, Nguyen Vu QH. Correlation between HER2 Expression and Clinicopathological Features of Breast Cancer: A Cross- Sectional Study in Vietnam. Asian Pacific Journal of Cancer Prevention. 2020;21(4):1135-1142. doi: 10.31557/APJCP.2020.21.4.1135

6. Nguyen VB, Nguyen VVH, Tran BT, Le CV, Dang CT, Baek JH. Undifferentiated pleomorphic sarcoma of the thyroid: A case report and ƚiterature review. Clinical Case Reports. 2020;8(4):680-684. doi: 10.1002/ccr3.2710

7. Truong V, Tran DT, Dang C. Collision occurrence of meningioma and astrocytoma: A case report and literature review. Asian Journal of Neurosurgery. 2019;14(3):938. doi: 10.4103/ajns.AJNS_97_19

1. Phan THG, Paliogiannis P, Nasrallah GK, et al. Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences. 2020;78(5):2031-2057. doi: 10.1007/s00018-020-03693-7

2. Pau MC, Pantaleo A, Tsamesidis I, et al. Clinical impact of the two ART resistance markers, K13 gene mutations and DPC3 in Vietnam. PLOS ONE. 2019;14(4):e0214667. doi: 10.1371/journal.pone.0214667